Persecution of Jews in Italy

Roman and Byzantine Empires
Under Christian emperors, Jews were persecuted in the Roman and Byzantine Empires, including forced conversions to Christianity, forbidding Jews from marrying Christians, restricting Jews from holding public office, and Jews weren't allowed to own slaves.

Bishop Victor of Palermo confiscated synagogues and converted them to churches in 598.

Papacy
The popes of the papacy have made laws restricting Jewish people, which includes Jews being prohibited from holding public office (in 1078, 1215, and 1442), prohibited from the construction of synagogues (in 1442 and 1555), prohibited from testifying against Christians (in 1442), forced to live in ghettos (in 1555, 1775, the 1820s, and 1850), forced to wear a Jewish badge and hat (in 1215, 1218, and 1555), and expelled from the Papal States (in 1569 and 1593).

Blood libel
Over a dozen Jews are killed after being falsely blamed for the death of Simon of Trent in a blood libel, which falsely accuses Jews of having killed the Christian child for a ritual.

Modica massacre
In 1474, hundreds of Jews are killed by a Christian mob in Modica.