Inquisition

Massacres and Forced Conversions of 1391
Many of Spain's Jewish inhabitants were killed and many others were forced to convert and baptize to Christianity as a result of the religious persecution and pogroms which occurred in 1391.

Christian Inquisition
The Inquisition was a Christian tribunal initiated by Pope Innocent III to combat heresy. The Spanish Inquisition, established in 1478, was used to maintain Catholic orthodoxy and to convert Jews and Muslims. Royal decrees issued in 1492 and 1502 ordered Jews and Muslims to convert or leave Spain. Due to the Alhambra decree and persecution in previous years, thousands of Jews converted to Christianity and thousands were expelled. Jews that converted back to Judaism were killed.

Many Spanish Jews left Spain for Portugal and were persecuted there too. The Portugal Inquisition targeted Jews to be expelled from Portugal or forcibly converted to Catholicism. In New Spain, the Spanish Empire in the New World, many Jews were executed for practicing the Jewish religion during the Mexican Inquisition.

Execution
Six Jews were burnt alive in Seville during February 1481 and 298 Jews were publicly burnt at the same place in November of the same year. Their property was taken by the Church. During 1511–15 in Sicily, 79 were killed by burning, and in 1511 to 1560, 441 Jews were sentenced to be executed.

Examples of Jews that were killed and their year of execution:
 * Francisca Nuñez de Carabajal with her children, Isabel, Catalina, Leonor, and Luis, 1596
 * Francisco Maldonado da Silva, 1639
 * Catalina Terongi, Rafael Valls and Rafael Benito, 1691
 * Maria Barbara Carillo, 1721
 * Ana de Castro, 1736