Persecution of Jews in Italy

Roman and Eastern Roman Empires
Under Christian emperors, Jews were persecuted in the Roman and Eastern Roman Empires, including forced conversions to Christianity, forbidding Jews from marrying Christians, restricting Jews from holding public office, and Jews weren't allowed to own slaves.

Bishop Victor of Palermo confiscated synagogues and converted them to churches in 598.

Papacy
The popes of the papacy have made laws restricting Jewish people, which includes Jews being prohibited from holding public office (1078, 1215, and 1442), prohibited from the construction of synagogues (1442 and 1555), prohibited from testifying against Christians (1442), forced to live in ghettos (1555, 1775, 1823, and 1850), forced to wear a Jewish badge and hat (1215, 1218, and 1555), and expelled from the Papal States (1569 and 1593).

Frederick II
King Frederick II of Sicily in 1310 prohibited Jewish doctors from attending to Christian patients in Sicily and in 1312 ordered Jews to live outside the city wall of Palermo in a ghetto.

Jewish ghettos
Ghettos were set up in Palermo in 1312, Venice in 1516, Rome in 1555, Florence and Siena in 1571, Verona in 1602, Padua in 1603, Mantua in 1612, Ferrara in 1624, Modena in 1638, and Correggio in 1779 for Jews to be forced to reside within.

Modica massacre
In 1474, hundreds of Jews are killed by a Christian mob in Modica.

Blood libel
Over a dozen Jews are killed after being falsely blamed for the death of Simon of Trent in 1475 in a blood libel, which falsely accuses Jews of having killed the Christian child for a ritual.